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April 2001

The Validation of Medical Histories in Kindreds

Arch Dermatol. 2001;137(4):506-507. doi:

In the review of the article on the validity of the assessment of a family history of melanoma and dysplastic nevi, Pasquini1 underscores the importance of validating probands' health information about members of their kindreds with an independent source. The reviewed authors2 did extend their evaluations of the family's medical histories to include both first- and second-degree relatives, even though recent guidelines on the care of patients with melanoma recommend only investigation of first-degree relatives. In the evaluation of an autosomal dominant disorder, it is imperative to evaluate at least through the second-degree relatives. In the instances of small kindreds, it is necessary to have medical histories beyond second-degree relatives.

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