Until now it has been assumed that hyperpigmentation during amiodarone treatment is exclusively due to dermal accumulation of a lipofuscin pigment.1,2 We describe here a patient with an absence of melanin in lesional sun-exposed epidermis and conclude that a block in melanosomal maturation is a major pathogenetic factor in photosensitivity and its distinctive discoloration.
Haas N, Schadendorf D, Hermes B, Henz BM. Hypomelanosis Due to Block of Melanosomal Maturation in Amiodarone-Induced Hyperpigmentation. Arch Dermatol. 2001;137(4):513-514. doi: