Hematoxylin-eosin–stained sections showed the overlying epidermis to be focally ulcerated in the center and covered by necrotic debris. The underlying lesion consisted of a malignant proliferation of neoplastic glands growing focally in papillary projections.
The glands consisted of tall columnar cells in pseudostratified array, alternating with mucin-secreting cells that stained positively for mucicarmine. Many nuclei were anaplastic, and scattered abnormal mitotic figures were present. The neoplastic growth appeared to be surrounded by dense fibroconnective tissue with scattered chronic inflammatory cells. Focal areas of necrosis were identified. Carcinoembryonic antigen was strongly positive throughout the tumor cells.
Ulcerated Papules of the Scrotum. Arch Dermatol. 2001;137(4):495-500. doi: