In Brazil, pruritic papular eruption (PPE) has been found in 11.7% of patients with human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS) (hereinafter HIV/AIDS) and has served as a dermatological marker of HIV infection.1 Cutaneous lesions are similar to prurigo or strophulus and have been likened to insect bites by the patients. Eosinophilia in HIV-positive patients may be associated with an immunodepressed status and possibly with increased serum IgE levels attributed to PPE or to the base disease.2 We investigated whether PPE could be considered a prurigo or strophulus caused by insect bites.
Rosatelli JB, Roselino AMF. Hyper-IgE, Eosinophilia, and Immediate Cutaneous Hypersensitivity to Insect Antigens in the Pruritic Papular Eruption of Human Immunodeficiency Virus. Arch Dermatol. 2001;137(5):672-673. doi: