We have read with interest the article by Toro et al,1 "Granuloma Annulare and Human Immunodeficiency Virus Infection," and the comment by Cohen2 in the same issue of the ARCHIVES. Toro et al1 report 34 cases of the association between these diseases and review 23 more from the English-language literature, including 2 cases of perforating granuloma annulare (PGA). Of their 34 cases, 2 were PGA, constituting a 6% prevalence.
Peñas PF, Jones-Caballero M, García-Díez A. Association Between Zalcitabine Therapy for Human Immunodeficiency Virus and Granuloma Annulare?. Arch Dermatol. 2001;137(7):964. doi: