I read the article by Itoh et al1 in the ARCHIVES with a sense of astonishment and bemusement. Why this article was ever published I simply cannot fathom! How on earth could this patient be categorized as having "intractable" acne when it seems she has not been adequately treated with the various proven oral antibiotics and diverse topical therapies such as retinoids, benzoyl peroxides? I know that far more dramatic clinical improvement would have occurred under energetic application of the various "standard" systemic and topical regimens now extant. It seems to this dermatologist that this patient was treated in an extremely pusillanimous manner.
Rudolph RI. Some Articles Should Just Not Be Published. Arch Dermatol. 2001;137(7):964-965. doi: