The classification of large-plaque parapsoriasis (LPP) has been debated for many years. Today it is widely agreed that LPP is an early (premycotic) stage of cutaneous T-cell lymphoma (CTCL).1 However it is not known why only 0% to 46% of cases progress into clear-cut lymphoma, nor do there seem to be reasonable criteria for predicting which patients with LLP will develop a more severe form of CTCL.
Rubegni P, De Aloe G, Di Renzo M, Pompella G, Pasqui AL, Auteri A, Andreassi L, Fimiani M. Cytokine Production Profile of Peripheral Blood Mononuclear Cells in Patients With Large-Plaque Parapsoriasis. Arch Dermatol. 2001;137(7):966-967. doi: