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August 2001

Ceramide-Dominant, Barrier-Repair Lipids Improve Childhood Atopic Dermatitis

Arch Dermatol. 2001;137(8):1110-1112. doi:

We report here the initial promising results of a phase 1 trial of a ceramide-dominant, barrier-repair moisturizer in childhood atopic dermatitis (AD). Atopic dermatitis is a multifactorial, polygenic skin disorder that affects up to 20% of preadolescent children in Western countries1 and is commonly viewed as immunologic in origin.2,3 Whereas anti-inflammatory agents (eg, topical glucocorticoids and immunosuppressive agents) are mainstays of therapy in AD, reliance on these drugs carries potential risks, particularly in children, and AD typically relapses or flares after discontinuation of therapy.3

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