I read with great interest the recent vignette on the treatment of warts with Candida antigen injection by Phillips et al.1 In it, the authors mention that injection of warts with Candida antigen has been adopted by some physicians without the support of published studies. However, I am aware of 1 case series published in Japanese by Harada2 illustrating the successful treatment of warts with Candida vaccine. Also, Candida intralesional injection immunotherapy of warts was the subject of 2 recent scientific posters at the 58th annual meeting of the American Academy of Dermatology.3,4 Indeed, there appears to be growing interest among the dermatological community regarding this treatment modality. There are currently 2 ongoing open-label comparison studies involving Candida immunotherapy of warts.3,4 As Phillips and colleagues suggest, published randomized controlled trials are needed to evaluate more rigorously the efficacy of this novel therapeutic approach.
Signore RJ. Candida Immunotherapy of Warts. Arch Dermatol. 2001;137(9):1250-1251. doi: