In the March issue of the ARCHIVES, de Villiers and Ruhland1 reported that the proinflammatory cytokines interleukin 17 and interferon-γ activate in vitro the promoter of human papillomavirus (HPV) 20, a human papillomavirus associated with epidermodysplasia verruciformis (EV), which may induce replication of this virus. They conclude that EV-HPV infection (eg, HPV-5) does not play an active role in the pathogenesis of psoriasis, but that the virus, present latently in the skin, could become activated by cytokines.
Majewski S, Jablonska S, Favre M, Orth G. Cytokines May Favor a Role for Human Papillomaviruses in the Pathogenesis of Psoriasis. Arch Dermatol. 2001;137(10):1373. doi: