Blood dyscrasias include a variety of malignant and premalignant conditions of blood or bone marrow such as leukemias, myelodysplasia, and myeloproliferative disorders. These disorders are associated with a broad range of cutaneous findings, ranging from recurrent cutaneous infections to malignant cell invasion. However, these eruptions are not associated with tissue eosinophilia, as seen in immunobullous diseases, parasitic infections, drug reactions, and cutaneous T-cell lymphoma. We describe 4 patients with blood dyscrasias who presented with a persistent, erythematous, pruritic, papulonodular eruption characterized by dermal lymphocytic and eosinophilic infiltrates. As our patients share many features with patients described elsewhere,1- 7 we have named this unique eruption eosinophilic dermatosis of myeloproliferative disease.
Byrd JA, Scherschun L, Chaffins ML, Fivenson DP. Eosinophilic Dermatosis of Myeloproliferative Disease: Characterization of a Unique Eruption in Patients With Hematologic Disorders. Arch Dermatol. 2001;137(10):1378-1380. doi: