WE ARE delighted to bring this special Genome issue of the Archives of Dermatology to our readers. This month the Archives of Dermatology, JAMA, and most of the ARCHIVES journals will devote most or all of their issues to genomic medicine. With the recent advances in technology, biotechnology, and bioinformatics, physicians more than ever are confronted with scientific and ethical questions raised by genetic and genomic research.
Genetics has traditionally been defined as the study of the pattern of trait inheritance. Students of biology are all cognizant of the "father" of modern genetics, Gregor Mendel, and his genetically insightful botanical research during the 19th century. Throughout the 20th century, rapid progress in both prokaryotic and eukaryotic molecular biology has shed further light on how functional defects in specific proteins can lead to the disease phenotype and how these functional changes are preserved and transmitted as permanent changes in the human DNA sequence (ie, mutations). With the fusion of classic genetics and molecular biology, the field of molecular genetics was born.
Tsao H, Arndt KA. The Genomics Issue. Arch Dermatol. 2001;137(11):1409. doi:10.1001/archderm.137.11.1409