Topical corticosteroids are effective for treating plaque psoriasis.1 Benefits of their use include ease of application, rapid clinical response, and few adverse effects. Most practitioners generally accept twice-daily application of topical corticosteroids as the standard frequency,2 despite lack of evidence that such a schedule is optimal.3 Because of the depot effect of topical corticosteroids,4 it might be possible to reduce the frequency of their applications without affecting treatment efficacy. If proven as efficacious as twice-daily application, once-daily application of topical corticosteroid creams would enable patients with psoriasis to simplify their treatment regimens. Once-daily usage would also result in a decreased total cost of treatment, as well as lessening potential risks associated with the use of topical corticosteroid preparations, while maintaining therapeutic benefits.
Kanzler MH, Chui C, Gorsulowsky DC. Once-Daily vs Twice-Daily Triamcinolone Acetonide Cream for Psoriasis. Arch Dermatol. 2001;137(11):1529-1532. doi: