Systemic therapies for severe childhood psoriasis have not been evaluated and are used empirically, and retinoids are considered a second line of therapy. The safety and efficacy of cyclosporine therapy have been extensively studied in severe adult and childhood atopic dermatitis and in adult psoriasis. We describe 4 patients who were treated with cyclosporine for severe drug-resistant psoriasis (neonatal erythrodermic psoriasis, acral pustular psoriasis, generalized pustular psoriasis, and very severe erythrodermic psoriasis). Because of unsatisfactory results, cyclosporine therapy was discontinued in all 4 cases. Despite the inefffectiveness of cyclosporine therapy in these unusual cases, we discuss a possible role for cyclosporine in the treatment of childhood psoriasis. Notably, higher doses of cyclosporine might be used in cases involving young children.
Mahé E, Bodemer C, Pruszkowski A, Teillac-Hamel D, de Prost Y. Cyclosporine in Childhood Psoriasis. Arch Dermatol. 2001;137(11):1532-1533. doi: