Primary cutaneous large B-cell lymphoma (PCLBCL) of the leg is a recently recognized distinct type of B-cell neoplasm that has an intermediate prognosis.1- 5 Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive, usually fatal disease that often involves the skin and central nervous system (CNS).2- 4 Primary cutaneous forms of IVLBCL are thought to have a more favorable prognosis.2,3 We describe the first reported case of PCLBCL of the leg relapsing initially as a cutaneous IVLBCL and then occurring in the CNS.
Kamath NV, Gilliam AC, Nihal M, Spiro TP, Wood GS. Primary Cutaneous Large B-Cell Lymphoma of the Leg Relapsing as Cutaneous Intravascular Large B-Cell Lymphoma. Arch Dermatol. 2001;137(12):1657-1658. doi: