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December 2001

Primary Cutaneous Large B-Cell Lymphoma of the Leg Relapsing as Cutaneous Intravascular Large B-Cell Lymphoma

Arch Dermatol. 2001;137(12):1657-1658. doi:

Primary cutaneous large B-cell lymphoma (PCLBCL) of the leg is a recently recognized distinct type of B-cell neoplasm that has an intermediate prognosis.15 Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive, usually fatal disease that often involves the skin and central nervous system (CNS).24 Primary cutaneous forms of IVLBCL are thought to have a more favorable prognosis.2,3 We describe the first reported case of PCLBCL of the leg relapsing initially as a cutaneous IVLBCL and then occurring in the CNS.

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