Necrobiosis lipoidica (NL) affects 0.3% of patients with diabetes mellitus.1 It can occur in patients without diabetes mellitus, 42% of whom have an impaired glucose tolerance test result (54% of whom have a strong family history of diabetes). Of patients with NL, 84% have more than 1 plaque, and 50% have more than 4. Plaques can be associated with paraesthesia, pruritus, or pain and can be disabling when associated with ulceration.2 There is no satisfactory treatment for NL.
Patel GK, Mills CM. A Prospective Open Study of Topical Psoralen–UV-A Therapy for Necrobiosis Lipoidica. Arch Dermatol. 2001;137(12):1658-1660. doi: