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December 2001

A Prospective Open Study of Topical Psoralen–UV-A Therapy for Necrobiosis Lipoidica

Arch Dermatol. 2001;137(12):1658-1660. doi:

Necrobiosis lipoidica (NL) affects 0.3% of patients with diabetes mellitus.1 It can occur in patients without diabetes mellitus, 42% of whom have an impaired glucose tolerance test result (54% of whom have a strong family history of diabetes). Of patients with NL, 84% have more than 1 plaque, and 50% have more than 4. Plaques can be associated with paraesthesia, pruritus, or pain and can be disabling when associated with ulceration.2 There is no satisfactory treatment for NL.

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