The report by Brooke and colleagues1 on discordance between facial wrinkling and presence of basal cell carcinoma (BCC) raises some methodological issues. This small case-control study was designed to substantiate the observation made by the authors in their daily clinical practice that patients with BCC had less facial wrinkling than patients who did not have BCC. Using logistic regression analysis, they found that an increasing grade of wrinkling was associated with a progressive reduction in risk of developing a BCC, after adjusting for age, sex, and smoking history.
Corona R. Facial Wrinkling and Basal Cell Carcinoma. Arch Dermatol. 2002;138(2):267-268. doi:10.1001/archderm.138.2.266