Granuloma annulare (GA) is a papular skin eruption with annular configuration and typical histologic findings that may occur as an idiopathic condition or associated with systemic diseases.1 Treatment with cyclosporine has been tried with success in a few cases.2 Leukemias of large granular lymphocytes (LGLs) are defined as clonal proliferations of T or natural killer (NK) cells that have LGL morphologic characteristics and express NK cell–associated markers.3 In most cases LGLs are CD8+/T-cell receptor (TCR) positive. Cyclosporin A therapy has been useful to control manifestations associated with LGL proliferations.4 We describe a patient with disseminated GA and CD4+ T-cell LGL leukemia whose skin lesions responded to cyclosporine treatment.
Granjo E, Lima M, Lopes JM, Fernandes JC, Antunes I, Candeias J, Matutes E. Response to Cyclosporine in a Patient With Disseminated Granuloma Annulare Associated With CD4+/CD8+(dim)/CD56+ Large Granular Lymphocytic Leukemia. Arch Dermatol. 2002;138(2):274-276. doi:10.1001/archderm.138.2.266