The biopsy specimen showed acanthosis of the epidermis, with perifollicular hyperkeratosis. The follicular infundibulum near the point of entry of the apocrine gland was obstructed by a keratin plug. A moderate inflammatory infiltration was present. Local application of betamethasone valerate cream relieved the pruritus and resulted in improvement of the skin lesions.
Fox-Fordyce disease affects the apocrine sweat glands, with involvement of the axillae and, less often, the genital area or areolae. Rare sites of this disease are the perineum, lips, navel, and presternal region, which are other anatomical areas with increased apocrine sweat glands.
Itchy Papules of the Axillae. Arch Dermatol. 2002;138(2):259-264. doi:10.1001/archderm.138.2.259