Evidence-Based Dermatology: Research Commentary
March 2002

Prevention of Atopic Eczema: A Dream Not So Far Away?

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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Dermatol. 2002;138(3):391-392. doi:10.1001/archderm.138.3.391

Probiotics are cultures of potentially beneficial bacteria of microflora of the healthy gut. Previous epidemiological studies that have suggested that there is an inverse relationship between infections and atopic disease. Kalliomaki and colleagues proposed that specific microbes in the commensal microflora of the gut during early life might be more important than sporadic infections in the prevention of atopic disease. They argue that commensal gastrointestinal microbes are the earliest and biggest stimulus for the development of gut-associated lymphoid tissue that may counter the skewed TH2 helper cell lymphocyte response that is characteristic of atopic disease. The objective of this double-blind, placebo-controlled, randomized parallel group study was to see whether atopic disease could be prevented in infants at high risk of developing atopic disease by giving cultures of Lactobacillus GG (Valio Ltd, Helsinki, Finland) prenatally to the mothers and postnatally for 6 months to the infants.

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