Routine hematoxylin-eosin staining of the biopsy specimens revealed slight epidermal acanthosis, hypergranulosis, and hyperkeratosis (Figure 2). There were characteristic distended keratinocytes with basophilic and finely vacuolated cytoplasm and coarse keratohyaline granules (Figure 3). A biopsy specimen from the right side of the groin was initially interpreted as verruca plana, which was attributed to sampling error. Two additional biopsy specimens from the groin revealed changes consistent with EDV. The results of human papillomavirus (HPV) typing by polymerase chain reaction and restriction fragment length polymorphism analyses were consistent with HPV-8.
Groin Eruption in an HIV-Positive Man. Arch Dermatol. 2002;138(4):527-532. doi:10.1001/archderm.138.4.527