We demonstrated that patients with familial NF1 had a greater frequency of Lisch nodules than those with sporadic NF1. Our study did not include patients with NF1 who had visual impairment or apparent optic nerve involvement and we did not analyze the relation between such ophthalmological manifestations and the absence or presence of Lisch nodules. Thus, our evidence is likely to suggest only the absence or presence, in other words, the severity of Lisch nodules, a part of eye manifestations.
Otsuka F, Kawashima T, Imakado S, Usaki Y, Hon-mura S. Absence of Lisch Nodules in Sporadic Neurofibromatosis Type 1 May Reflect Somatic Mosaicism—Reply. Arch Dermatol. 2002;138(6):840. doi:10.1001/archderm.138.6.838