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August 2002

Androgenetic Alopecia: Analysis of Proliferation and Apoptosis

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Arch Dermatol. 2002;138(8):1101-1102. doi:10.1001/archderm.138.8.1098

Androgenetic alopecia is progressive balding characterized by diminution in hair shaft diameter.1 It is unknown if there is an altered degree of proliferation or cell death (apoptosis) in androgenetic alopecia.

Two-millimeter punch or 9-mm wedge biopsy specimens were obtained from donor and recipient regions from 12 men with androgenetic alopecia, aged 19 to 51 years (mean, 35 years), undergoing hair transplantation. Analysis included terminal-vellus and anagen–catagen-telogen (anagen-other) ratios and hair shaft diameter. Expression of bax, bcl-2, Ki67, hsp70, cyclin D1, and p53 was immunohistochemically analyzed in all hair follicles as numbers of labeled cells divided by the total numbers of cells located in the basal layer of follicles. The t test was used to compare the results.

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