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September 2002

Limitations in Enzyme-linked Immunosorbent Assays for Antibodies Against Desmogleins 1 and 3 in Patients With Pemphigus

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Arch Dermatol. 2002;138(9):1252-1253. doi:10.1001/archderm.138.9.1251

Commercially available enzyme-linked immunosorbent assays (ELISAs) have become available to measure the antibodies against desmoglein 1 (Dsg1) and desmoglein (Dsg3), which are associated with pemphigus vulgaris (PV) and pemphigus foliaceus.1,2 The advantages of these assays are that they may be more sensitive and specific than conventional indirect immunofluorescence (IIF) assays. In addition, the results are said to be more quantitative than those of IIF.3,4

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