Bogdan and coauthors1 have made a sophisticated and informative contribution in the continuing effort to optimize criteria for distinguishing Spitz nevi from malignant melanoma. It is disappointing that loss of heterozygosity and microsatellite instability in their 5 Spitz nevi were no different from that observed in malignant melanomas, so the quest must continue.
Cramer SF. Molecular and Cellular Pathogenesis of Spitz Nevi. Arch Dermatol. 2002;138(9):1254-1255. doi:10.1001/archderm.138.9.1251