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November 2002

Eosinophilic Dermatosis Associated With Hematologic Disorders: Not So Unique

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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Dermatol. 2002;138(11):1516. doi:10.1001/archderm.138.11.1515

We read with interest the recently published article by Byrd et al1 in which the authors coin the term eosinophilic dermatosis of myeloproliferative disease to refer to a unique eruption in patients with hematologic disorders. We do not believe that the described eruption is a new entity. The lesions in the 4 patients described bear a striking resemblance to previously described lesions2 in patients with chronic lymphocytic leukemia and other hematologic disorders.3 There is accumulating evidence that patients with hematologic malignancies, including myeloproliferative and, in particular, chronic lymphocytic leukemia, develop eosinophilic skin eruptions of various types. These have been called exaggerated arthropod bite lesions and insect bite lesions. These terms have been used in part because they were the accepted terminology and in part because, clinically and histologically, these lesions resemble arthropod bites with prominent eosinophilia. However, in our study,2 only 2 of 8 patients had a history of arthropod bites. We submit that the entity described by Byrd et al1 is in fact this same entity. The term eosinophilic dermatosis of myeloproliferative disease seems more accurate and appropriate than the more commonly used exaggerated arthropod bite lesions.

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