The clinical significance of retinoid-induced osteopenia can no longer be in doubt. A recent American study1 has confirmed the essential findings of an earlier Scandinavian study2: intake of increased amounts of dietary vitamin A is associated with increased risk for hip fractures. All retinoids, whether dietary or therapeutic, are likely to have similar qualitative effects on bone. In particular, all may have the potential to cause osteopenia.3 These newly published epidemiologic data raise additional questions that may be difficult to address in studies of dietary retinoids, but may be amenable to analysis in patients receiving therapeutic retinoids. For example, (1) Are some individuals more susceptible to retinoid-induced osteopenia than others? (2) Is retinoid-induced osteopenia reversible? (3) Can retinoid-induced osteopenia be prevented?
Milstone AM, Milstone LM. Is Retinoid-Induced Osteopenia Reversible?. Arch Dermatol. 2002;138(11):1516. doi:10.1001/archderm.138.11.1515