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Off-Center Fold
January 2003

Asymptomatic Pedunculated Nodule on the Leg of a 75-Year-Old Man—Diagnosis

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Arch Dermatol. 2003;139(1):93-98. doi:10.1001/archderm.139.1.93-a

Microscopic examination revealed a paucicellular lesion with polypoid architecture at scanning magnification. The epidermis was slightly acanthotic, but hyperpigmentation of the basal layer was absent. The dermis had an abundant myxoid stroma with scattered, bizarre, often multinucleated, stellate and spindle-shaped stromal cells. The nuclei of these cells were hyperchromatic, but the nucleoli were generally inconspicuous. Mitotic figures were not observed in multiple levels of sectioning. Many of the dilated blood vessels, some containing thrombi, had partially hyalinized vessel walls.

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