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February 2003

Direct Immunofluorescence of Plucked Hair in Pemphigus

Arch Dermatol. 2003;139(2):228. doi:10.1001/archderm.139.2.228

Pemphigus vulgaris and pemphigus foliaceus are autoimmune blistering diseases of the skin and the mucous membranes caused by autoantibodies directed against desmosomal glycoproteins desmoglein 1 (Dsg1) and Dsg3, resulting in the loss of keratinocyte cell-to-cell adhesion. The typical histological features are intraepidermal acantholytic blister formation with acantholysis often extending from the epidermis down the outer root sheaths (ORS) of hair follicles.1