We appreciate the interest shown by Drs Heenan and Taran in our recently published study on histological features of thin metastasizing melanomas.1 As we expressed in the "Comment" section, we were also surprised to find 10 nontumorigenic (radial growth phase) thin melanoma cases with a metastatic outcome. Six of the 10 cases showed extensive regression, involving more than 50% of the tumor surface area; 1 case had regression of less than 50% of the surface area; and 3 cases had no evidence of regression.
Guitart J, Lowe L, Piepkorn M, Prieto VG, Rabkin MS, Shea CR, White W, Barnhill RL. Metastasizing Thin Melanoma or Multiple Primary Melanomas?—Reply. Arch Dermatol. 2003;139(3):388-389. doi:10.1001/archderm.139.3.388-a