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April 2003

Evidence for Living Cells: DNA Fragments Are Not Enough

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Arch Dermatol. 2003;139(4):541. doi:10.1001/archderm.139.4.541-a

A bilayered skin substitute has been heavily promoted for the treatment of venous ulcers and other wounds on the basis that it is composed of viable cells. How long do these living cells survive? The study by Phillips and colleagues1 entitled "The Longevity of a Bilayered Skin Substitute After Application to Venous Ulcers" appears to address this issue. The authors' stated objective is "to determine the longevity of allogeneic fibroblasts and keratinocytes in a bilayered skin substitute in patients with venous leg ulcers."