A 43-year-old white man presented with fever and erythematous plaques that had developed in the right malar area and both ears 3 days after he had undergone intravenous cytarabine and idarubicin hydrochloride chemotherapy for acute myelogenous leukemia. The lesions were exquisitely painful and progressed to involve the periorbital and periauricular areas bilaterally. Similar lesions had developed on his upper back area after the first cycle of chemotherapy, 1 month earlier, but they had spontaneously resolved.
Crawford GH, Chu AY, Halpern M, James WD. Erythematous Facial Plaques in a Patient With Leukemia—Quiz Case. Arch Dermatol. 2003;139(4):531-536. doi:10.1001/archderm.139.4.531-a