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June 2003

A Pig Farmer With Pruritic Pink Papules and Plaques—Diagnosis

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Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Dermatol. 2003;139(6):803-808. doi:10.1001/archderm.139.6.803-a

Biopsy specimens of the skin lesions and lungs showed a granulomatous, angiocentric, angiodestructive infiltrate composed of an admixture of epithelioid histiocytes, small lymphocytes, and medium to large pleomorphic lymphocytes. Cultures of the tissue were negative for fungi, bacteria, and mycobacteria. Immunostaining of the skin and lung biopsy tissue was positive for CD45 (large anaplastic cells), CD20 (large anaplastic cells), CD3 (reactive T cells), and CD43. Taken together, the biopsy findings were consistent with a malignant lymphoma of the large-cell type with B-cell phenotype, associated with numerous reactive T cells and extensive necrosis, so-called lymphomatoid granulomatosis.

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