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Comment & Response
September 2003

The Use of ELISA to Detect Desmoglein Antibodies in a Pregnant Woman and Fetus

Author Affiliations
  • 1Sapporo, Japan
  • 2Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita-ku, Sapporo 060-8638, Japan, (e-mail: kmatsum@med.hokudai.ac.jp)
  • 3Sapporo
Arch Dermatol. 2003;139(9):1217-1218. doi:10.1001/archderm.139.9.1217

The desmoglein (Dsg) enzyme-linked immunosorbent assay (ELISA) is a sensitive and specific test for pemphigus vulgaris (PV),1,2 which, during pregnancy, is exceedingly rare.3 To our knowledge, the clinical patterns of PV activity monitored using Dsg ELISA during pregnancy and after delivery have not been reported. Transplacental anti-Dsg antibody transfer has not previously been confirmed using Dsg ELISA.

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