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November 2003

Histopathologic Findings of Granuloma Caused by Polymethylmethacrylate Microspheres

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Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Dermatol. 2003;139(11):1505. doi:10.1001/archderm.139.11.1505-a

We read with great interest the article by Reisberger et al1 about a case of foreign body granulomas that were caused by polymethylmethacrylate microspheres (known hereafter as Artecoll; Rofil Medical International, Breda, the Netherlands) and that were successfully treated with allopurinol. We think that this is a good new alternative to bear in mind for the treatment of foreign body granulomas due to aesthetic microimplants. These cases frequently represent a therapeutic challenge, and alternatives for their treatment are always welcome. However, the histologic findings illustrated in the article are consistent with silicone granulomas but not with those caused by the use of Artecoll.

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