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December 2003

Tender Subcutaneous Nodules in a Patient With AIDS—Diagnosis

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Arch Dermatol. 2003;139(12):1647-1652. doi:10.1001/archderm.139.12.1647-a

The biopsy specimen showed an extensive lobular panniculitis with a mixed neutrophilic, eosinophilic, and lymphocytic inflammatory infiltrate. A leukocytoclastic vasculitis with focal necrosis was present. Rare enlarged cells (Figure 2, arrow) were found in hematoxylin-eosin–stained sections, which demonstrated abundant vacuolar and granular eosinophilic cytoplasm. Deeper levels in the specimen revealed an elongate and ameboid cell with a villouslike cell surface that had an eccentric nucleus containing a single dense, central nucleolus.

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