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The biopsy specimen revealed large cystic spaces within the dermis. Two cell layers of the cystic wall were evident: outer cuboidal cells and inner columnar cells with decapitation secretion. These findings were consistent with multiple apocrine hidrocystomas. A diagnosis of Schopf-Schulz-Passarge syndrome was made. For skin cancer prophylaxis and possible treatment of both hyperkeratosis and apocrine hidrocystomas, acitretin therapy (25 mg/d) was initiated. There was minimal improvement of the hyperkertosis, and the acitretin therapy was discontinued.
Multiple Eyelid Cysts With Palmoplantar Hyperkeratosis—Diagnosis. Arch Dermatol. 2004;140(2):231-236. doi:10.1001/archderm.140.2.231-b