Drug-induced pemphigus is a well-documented entity. Since the first report of pemphigus activation in 1969, many other drugs that can triggerpemphigus foliaceus have been described in the literature . In the literaturesearch, all of the drugs that have been identified as offending agents havebeen systemic.1,2 Very little has been written about localized pemphigus follaceus induced by topical treatment.
Lin R, Ladd, Jr DJ, Powell DJ, Way BV. Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment. Arch Dermatol. 2004;140(7):889-890. doi:10.1001/archderm.140.7.889