A skin biopsy specimen from the border of the ulcer demonstrated endothelial cell nuclear inclusions with a clear halo and cytoplasmic perinuclear inclusionsconsistent with CMV infection (Figure 3). These findings were confirmed by immunohistochemical tests for CMV antigen.Histologic and immunohistochemical studies revealed no evidence of HSV infection within or surrounding the ulcer.
Perianal Ulcer in a Patient With AIDS—Diagnosis. Arch Dermatol. 2004;140(7):877-882. doi:10.1001/archderm.140.7.877-f