The concept that specific cutaneous markers can be used to diagnose systemic diseases or malformations has always been of great interest to physicians. These associations are almost always noted by an astute clinician and then passed on by way of teaching, case reports, case series, review articles, and in textbooks. Modern medical science is advancing at an unprecedented pace; however, many of these clinically relevant hypotheses are never tested with traditional scientific methodology.
Drolet BA, Boudreau C. When Good Is Not Good EnoughThe Predictive Value of Cutaneous Lesions of the Lumbosacral Region for Occult Spinal Dysraphism. Arch Dermatol. 2004;140(9):1153-1155. doi:10.1001/archderm.140.9.1153