Two observations of the successful treatment of Hailey-Hailey disease with topical tacrolimus ointment were recently reported,1,2 including the article by Sand and Thomsen1 in the Cutting Edge section of the ARCHIVES. It is suggested that the mechanism of action of topical tacrolimus in this disease might be related to the immunomodulating effect of the compound.1 We recently used topical tacrolimus in a patient with Hailey-Hailey disease and observed a complete failure of this therapy.
Laffitte E, Panizzon RG. Is Topical Tacrolimus Really an Effective Therapy for Hailey-Hailey Disease?. Arch Dermatol. 2004;140(10):1282. doi:10.1001/archderm.140.10.1282-a