During a randomized controlled trial comparing methotrexate with cyclosporine in the treatment of moderate-to-severe psoriasis, an unexpectedly high number of patients (12/43) had to discontinue methotrexate treatment because of increases in transaminase levels.1 We explored whether these increases were associated with the sex or age of the patients, preexistence of steatosis hepatis, and amount of alcohol consumption (Table).
Heydendael VMR, Spuls PI, Bossuyt PMM, Bos JD, de Rie MA. Analysis of Risk Factors in Psoriatic Patients With Methotrexate-Induced Increases in Transaminase Levels. Arch Dermatol. 2004;140(10):1289-1290. doi:10.1001/archderm.140.10.1289