November 2004

Nephrogenic Fibrosing Dermopathy: Are ACE Inhibitors the Missing Link?

Author Affiliations

Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004

Arch Dermatol. 2004;140(11):1401. doi:10.1001/archderm.140.11.1401

Nephrogenic fibrosing dermopathy (NFD) is a recently described cutaneous fibrosing disorder seen exclusively in patients with renal failure.1 This entity is characterized by progressive skin hardening and induration and differs from scleromyxedema by the absence of plasma cells on histologic evaluation and a lack of paraproteinemia. It differs from scleroderma in its morphology, distribution, histopathology, and in lacking anti–Scl-70 antibodies.1

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