The provocative arsphenamin reaction in the blood is a familiar phenomenon. In many clinics, when a patient suspected of having syphilis gives a negative Wassermann reaction, an injection of arsphenamin is given; then the blood is tested at daily intervals thereafter, because it apparently has been shown that after the injection of arsphenamin the Wassermann reaction will be positive in some cases.
It is our purpose to call attention to a similar reaction taking place in the spinal fluid. We report several cases in which, after either intravenous or intraspinal injections, a negative spinal fluid became positive, or the positive pathologic findings were intensified. From the clinical standpoint, the phenomenon of intensification of symptoms relating to the central nervous system has frequently been described as occurring after treatment. To this phenomenon the term neurorecidive or neurorecurrence has been applied. One is not sure in these cases whether the resulting intensification
SOLOMON HC, KLAUDER JV. PROVOCATIVE REACTIONS IN THE CEREBROSPINAL FLUID IN NEUROSYPHILIS. Arch Derm Syphilol. 1920;2(6):679–691. doi:10.1001/archderm.1920.02350120007002