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December 1921

A PRELIMINARY REPORT ON THE THERAPEUTIC ACTION OF SILVER ARSPHENAMIN

Author Affiliations

NEW YORK

From the Department of Dermatology and Syphilology, Columbia University, College of Physicians and Surgeons.

Arch Derm Syphilol. 1921;4(6):737-749. doi:10.1001/archderm.1921.02350250016002
Abstract

Silver arsphenamin, which has been in use in Europe for more than two years, is now made in this country and was distributed for clinical purposes in October, 1920. Since that time 168 patients, to whom about 1,800 doses were given, have been treated in my service at the Vanderbilt Clinic and the City Hospital.

Silver arsphenamin is the sodium salt of silver-diamino-dihydroxyarseno-benzene and is produced by the action of silver salts on arsphenamin. It is a brownish black powder, soluble in cool water, alkaline in reaction, and containing about 20 per cent, of arsenic and 14 per cent, of silver. At first it was given in a dilution of 1:50 and later reduced to 1:40 per 0.1 gm. It may be given in greater concentration, but more dilute solutions were preferred because the drug in this way is introduced slowly by the gravity method, a very important factor, it

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