In view of the important rôle played by arsphenamin in the treatment of syphilis, all have been interested in the arsenical compounds that have been introduced since the original arsphenamin. All syphilographers have sought knowledge of the advantages and disadvantages of these compounds.
Silver arsphenamin contains 22.4 per cent. of arsenic, and 14.1 per cent, of silver. It is sold in ampules identical with those of neo-arsphenamin, in the form of a blackish-brown powder, in doses of from 0.05 to 0.30 gm., which is the largest dose, each dose being 0.05 gm. larger than the preceding one. It dissolves perfectly in a sterile solution of sodium chlorid, 5 c.c. for doses of from 0.05 to 0.15 gm., and 10 c.c. for the larger doses. When the first injections were made, some technical difficulties were encountered, owing to the dark color of the solution, which prevented the detection of blood in
DE MEDINA JB. SILVER ARSPHENAMIN IN THE TREATMENT OF SYPHILIS. Arch Derm Syphilol. 1922;5(3):321–324. doi:10.1001/archderm.1922.02350280026002