The experimental aspects of the various dermatoses associated with and following the ingestion of various medicaments have received little attention from dermatologists. This is quite readily understandable when one realizes that such investigation involves the most intricate problems of biochemical and physicochemical research. For this reason, therefore, most of the articles dealing with the question of drug eruptions from their experimental side have been written by physiologic chemists.
Notwithstanding the fact that most of our experimental evidence comes from those not primarily interested in dermatology, valuable contributions from the side of cutaneous medicine have been made, in calling attention to the appearance of such rashes and in properly ascribing the cause to the offending drug. We are, therefore, indebted to dermatologic literature for the first descriptions and the etiologic factors involved; and, moreover, in not a few cases, to productive research attempting to explain the ultimate cause.
With the introduction
WILE UJ, WRIGHT CS, SMITH NR. A PRELIMINARY STUDY OF THE EXPERIMENTAL ASPECTS OF IODID AND BROMID EXANTHEMS. Arch Derm Syphilol. 1922;6(5):529–541. doi:10.1001/archderm.1922.02360050002001