The causation of many diseases of the skin is involved in obscurity. It was in the hope of shedding light on some of the vexatious problems in etiology that the present work was undertaken.
The commonest skin disease encountered in practice is not an etiologic entity, but rather a type of cutaneous reaction which presents a clinical picture that has been catalogued under the name of eczema. There are some writers who, confronted with the perplexing difficulty of differentiating the characteristics of a dermatitis of external origin from one due to systemic causes, advocate the abandonment of the term eczema. We prefer to retain this designation but to confine it to an inflammation of the skin with certain characteristics not due to any external irritant. As soon as an eczematoid eruption is proved to be due to a local or external agent, it should cease to be regarded as an
SCHAMBERG JF, BROWN H. A STUDY OF THE BLOOD URIC ACID IN DISEASES OF THE SKIN, WITH PARTICULAR REFERENCE TO ECZEMA AND PRURITUSBASED ON AN ANALYSIS OF THE BLOOD OF 280 PATIENTS. Arch Derm Syphilol. 1923;8(6):801–817. doi:10.1001/archderm.1923.02360180057008