Of the many theories which have from time to time been offered in an attempt at explanation of this malady, none has been more alluring than that it is due to bacterial invasion. This possibility was first asserted by Murray, who believed he had found a specific causative organism—a strain of streptococcus which is known to bacteriologists as Streptococcus fecalis. For some years he contended that here was the long sought for primary etiologic factor, and by his persistent reports he won many adherents to his views. At present this theory has been largely discarded, partly because of lack of evidence as to the pathogenicity of Streptococcus fecalis and partly for the reason that vaccine treatment based on the use of Streptococcus fecalis is totally unsatisfactory.
More recently, J. M. Winfield,1 in presenting a review of cases concludes that 80 per cent. "had an infection of the skin covering
MONTAGUE JF. AN ORIGINAL BACTERIOLOGIC RESEARCH ON PRURITUS OF THE PERINEUM(PRURITUS ANI, VULVAE AND SCROTI). Arch Derm Syphilol. 1924;10(1):42–55. doi:10.1001/archderm.1924.02360250063004