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June 1928


Author Affiliations


From the University of Illinois, College of Medicine.

Arch Derm Syphilol. 1928;17(6):821-832. doi:10.1001/archderm.1928.02380120056006

In October, 1924, under the title "Progressive and Recurring Dermatofibroma, or Fibrosarcoma of the Skin," Darier1 described a type of neoplasm which he stated had not appeared before then in any nosologic or oncologic grouping, so far as a cursory search of the literature disclosed. He felt that the condition deserved a place as a special morbid type, because of the characteristic clinical and histologic features presented in the four cases reported by him.

He described the clinical picture, in brief, as that of a neoplastic lesion of the skin which has a peculiar appearance, its features being derived in part from the picture of sclerodema en placque, but chiefly from that of the neoplasms. The evolution of the disorder is progressive, and there is a marked resistance to treatment, together with a great tendency to rapid increase after destruction. The histologic picture seems to indicate that the growths

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